A systematic review on the effects of tACS on cognitive function within older adults

Background Novel interventions that delay the onset or progression of cognitive decline in older adults are extremely important, especially as proportion steadily grows. Data on transcranial Alternating Current Stimulation (tACS) suggests it may have potential for improving function; however, direct implication adults, including those with impairment is far less understood. It imperative to better understand effects tACS function within along treatment parameters if therapeutic utility be realized. Method For this reason, we performed a systematic review literature evaluate effectiveness functions adults. Databases were reviewed up February 2022, which initially produced 347 unique projects. Thirty-seven articles passed initial screening eligibility and full texts reviewed. Eligibility criteria included single multiple session frequency-specific applied purpose modulating performance one domains A total 14 reports met review, consisting 294 receiving tACS. Result The revealed show improvement cognitively intact (n = 5), mild 3), multi-etiological dementia Parkinson’s 2), whereas 2 Alzheimer’s 1 healthy aging report found no improvements. Gamma 7) Theta 6) frequencies largely targeted showed modulations memory, executive functioning, working gross measures. Conclusion Discussion will focus impact various stimulation experimental methods since significant heterogeneity these factors indicates need greater standardization. In summary, appears beneficial across ADRD continuum but intentional mapping parameter space standardized outcomes vital future translational efforts.